As a companion post to the listing of the most compact American cities with 100,000 or more residents, below is a list of the most spacious (largest area in square miles) American cities with 100,000 or more residents. It is interesting to note that only ten of the cities listed are located in the Northeast/Midwest. Also, at least 13 of the cities would be considered suburbs.
More than 500 square miles
- Anchorage, Alaska = 1,961 square miles
- Jacksonville, Florida = 885 square miles
- Houston, Texas = 627 square miles
- Oklahoma City, Oklahoma = 620 square miles
- Nashville, Tennessee = 526 square miles
- Phoenix, Arizona = 517 square miles
- Los Angeles, California = 503 square miles
Between 251 and 500 square miles
- Virginia Beach, Virginia = 497 square miles
- San Antonio, Texas = 465 square miles
- Corpus Christi, Texas = 460 square miles
- Louisville, Kentucky = 399 square miles
- Dallas, Texas = 386 square miles
- San Diego, California = 372 square miles
- Indianapolis, Indiana = 368 square miles
- Chesapeake, Virginia = 351 square miles
- New Orleans, Louisiana = 350 square miles
- Fort Worth, Texas = 349 square miles
- Memphis, Tennessee = 324 square miles
- Kansas City, Missouri = 319 square miles
- Augusta, Georgia = 307 square miles
- New York City, New York = 305 square miles
- Charlotte, North Carolina = 298 square miles
- Lexington, Kentucky = 286 square miles
- Austin, Texas = 272 square miles
- El Paso, Texas = 256 square miles
- Macon, Georgia = 255 square miles
Between 100 and 250 square miles
- Tucson, Arizona = 236 square miles
- Chicago, Illinois = 234 square miles
- Columbus, Ohio = 223 square miles
- Columbus, Georgia = 221 square miles
- Huntsville, Alabama = 215 square miles
- Albuquerque, New Mexico = 190 square miles
- Norman, Oklahoma = 189 square miles
- Tulsa, Oklahoma = 187 square miles
- Colorado Springs, Colorado = 186 square miles
- Scottsdale, Arizona = 184 square miles
- San Jose, California = 180 square miles
- Peoria, Arizona = 178 square miles
- Tampa, Florida = 171 square miles
- Wichita, Kansas = 164 square miles
- Mobile, Alabama = 159 square miles
- Charleston, South Carolina = 157 square miles
- Denver, Colorado = 155 square miles
- Montgomery, Alabama = 155 square miles
- Aurora, Colorado = 154 square miles
- Birmingham, Alabama = 152 square miles
- Brownsville, Texas = 148 square miles
- Fayetteville, North Carolina = 148 square miles
- Portland, Oregon = 145 square miles
- Raleigh, North Carolina = 145 square miles
- Bakersfield, California = 144 square miles
- Chattanooga, Tennessee = 143 square miles
- Detroit, Michigan = 143 square miles
- Philadelphia, Pennsylvania = 143 square miles
- Las Vegas, Nevada = 136 square miles
- Columbia, South Carolina = 135 square miles
- Hampton, Virginia = 135 square miles
- St. Petersburg, Florida = 133 square miles
- Winston-Salem, North Carolina = 132 square miles
- Greensboro, North Carolina = 131 square miles
- Omaha, Nebraska = 131 square miles
- Kansas City, Kansas = 128 square miles
- Mesa, Arizona = 125 square miles
- Lubbock, Texas = 124 square miles
- Shreveport, Louisiana = 121 square miles
- Cape Coral, Florida = 120 square miles
- Athens, Georgia = 118 square miles
- Little Rock, Arizona = 116 square miles
- Fresno, California = 112 square miles
- Fort Wayne, Indiana = 111 square miles
- Abilene, Texas = 111 square miles
- Orlando, Florida = 111 square miles
- Salt Lake City, Utah = 109 square miles
- Savannah, Georgia = 109 square miles
- Henderson, Nevada = 108 square miles
- Jackson, Mississippi = 107 square miles
- Killeen, Texas = 106 square miles
- Palmdale, California = 106 square miles
- Reno, Nevada = 106 square miles
- Surprise, Arizona = 106 square miles
- Rio Rancho, New Mexico = 104 square miles
- Tallahassee, Florida = 103 square miles
- North Las Vegas, Nevada = 101 square miles
- Arlington, Texas = 100 square miles
- Sacramento, California = 100 square miles
Source: en.wikipedia.org