FILM
James Bond – multiple actors (see image above) and multiple James Bond 007 films
Ethan Hunt – Tom Cruise in multiple Mission Impossible films
Jason Bourne – Matt Damon in multiple Bourne films
George Smiley – Gary Oldman in Tinker Tailor Soldier Spy
Harry Tasker – Arnold Schwarzenegger in True Lies
Jack Ryan – multiple actors in multiple Jack Ryan films
Samir Horn – Don Cheadle in Traitor
Austin Powers – Mike Myers in multiple Austin Powers films
Alec Leamas – Richard Burton in The Spy Who Came in From the Cold
Roger Thornhill – Cary Grant in North by Northwest
Napoleon Solo – Henry Cavill in The Man From U.N.C.L.E. – added 5/31/22
Felix Leiter – multiple actors in multiple James Bond 007 films
Gaby Teller – Alicia Vikander in The Man From U.N.C.L.E. – added 5/31/22
Peter Joshua – Cary Grant in Charade
T.R. Devlin – Cary Grant in Notorious
Matt Helm – Dean Martin in multiple Matt Helm films
Derek Flint – James Coburn in multiple Derek Flint films
Agent K – Tommy Lee Jones in multiple Men in Black films
TELEVISION
Illya Kuryakin – David McCallum in The Man from U.N.C.L.E.
River Cartright – Jack Lowden in Slow Horses – added 5/31/22
Jackson Lamb – Gary Oldman in Slow Horses – added 5/31/22
Napoleon Solo – Robert Vaughn in The Man from U.N.C.L.E.
James Phelps – Peter Graves in Mission Impossible
Sydney Bristow – Jennifer Garner in Alias
Penguins of Madagascar – cartoon by the same name
Maxwell Smart – Don Adams in Get Smart
Agent 99 – Barbara Feldon in Get Smart
Jack Bauer – Kiefer Sutherland in 24
Rollin Hand – Martin Landau in Mission Impossible
Barney Collier – Greg Morris in Mission Impossible
Cinnamon Carter – Barbara Bain in Mission Impossible
Boris Badenov – Rocky & Bullwinkle
Natasha Fatale – Rocky & Bullwinkle
Fearless Leader – Rocky & Bullwinkle
problogic
Panethos 